Zepbound

What are the most common side effects of Zepbound?

The most common side effects of Zepbound are listed below. Tell your healthcare provider if you have any of these side effects that bother you.

• Nausea/vomiting
• Diarrhea/constipation
• Stomach pain, upset stomach or indigestion, acid reflux
• Pain, itching, swelling, or redness near the injection site
• Tiredness
• Allergic reactions
• Burping
• Hair loss

There may be other side effects of Zepbound that are not listed here. Contact your healthcare provider if you think you are having a side effect of a medicine. In the U.S., you can report side effects to the FDA at www.fda.gov/medwatch or by calling 800-FDA-1088. In Canada, you can report side effects to Health Canada at www.health.gc.ca/medeffect or by calling 866-234-2345.

What are the serious side effects of Zepbound?

While less common, the most serious side effects of Zepbound are described below, along with what to do if they happen.

Severe Allergic Reactions. Zepbound may cause allergic reactions, which can be serious. Stop using Zepbound and get help right away if you have any of the following symptoms of a serious allergic reaction.

• Breathing problems or wheezing
• Racing heart
• Fever or general ill feeling
• Swollen lymph nodes
• Swelling of the face, lips, mouth, tongue, or throat
• Trouble swallowing or throat tightness
• Itching, skin rash, or pale red bumps on the skin called hives
• Nausea or vomiting
• Dizziness, feeling lightheaded, or fainting
• Stomach cramps
• Joint pain

Thyroid Tumors. Zepbound may cause you to develop thyroid tumors. Some of these tumors could be cancerous. Tell your healthcare provider right away if you notice any of the following symptoms of a thyroid tumor.

• Swelling or a lump in your neck
• Hoarseness
• Trouble swallowing
• Trouble breathing

Pancreatitis. Zepbound may cause inflammation of the pancreas, which is called pancreatitis. Stop using Zepbound and call your healthcare provider right away if you have symptoms of pancreatitis including vomiting or severe pain in the upper part of your belly that travels to your back.

Gallbladder Problems. Using Zepbound can cause gallbladder problems, including cholecystitis and cholelithiasis(also known as gallstones). Call your healthcare provider right away if you have any of the following symptoms.

• Your skin or the whites of your eyes turning yellowish in color (also called jaundice)
• Fever
• Pain in your upper stomach area
• Stool (poop) that is clay-colored

Low Blood Sugar (Hypoglycemia).Zepbound can cause low blood sugar, especially when used with insulin or other medicines that increase your insulin levels. Hypoglycemia can be serious and may lead to death. Your dose of insulin or other diabetes medicine may need to be lowered to decrease your risk of low blood sugar. Do not use Zepbound and call your healthcare provider right away if you have any of the following symptoms of hypoglycemia.

• Headache
• Crankiness or anxiety
• Hunger
• Dizziness or confusion
• Blurry vision
• Slurred speech
• Sweating
• Feeling jittery or shakiness
• Fast heartbeat
• Seizures

Kidney Damage.Kidney damage can happen when using Zepbound. Call your healthcare provider right away if you have any of the following symptoms of kidney damage.

• Reduced need to pee
• Swelling in your feet, ankles, or legs
• Weakness or unusual tiredness
• Difficulty catching your breath or chest pain/pressure
• Confusion
• Nausea
• Seizures

Severe Stomach Problems. Severe stomach problems may happen with Zepbound. Call your healthcare provider if you have severe nausea, vomiting, or diarrhea.

Vision Changes.Zepbound may cause your vision to worsen when you start using the medicine or start a higher dose. Tell your healthcare provider if you develop new vision problems. If you have a condition called diabetic retinopathy, your vision may temporarily worsen when you start Zepbound or use a higher dose. Make sure that you keep all appointments to have your vision checked.

Suicidal Thoughts and Actions.Zepbound may cause suicidal thoughts or actions in a small number of people. If you are about to harm yourself, call 911 or call or text 988, the Suicide & Crisis Lifeline. Call your healthcare provider right away if you have any of the following symptoms.

• New or increased thoughts of suicide or death
• Suicide attempt
• New or increased feelings of anxiety, depression, or other unusual changes in mood or behavior

Usual adult zepbound dose for weight loss

Initial dose: 2.5 mg under the skin (subcutaneously) once a week.

After 4 weeks: The dosage should be increased to 5 mg subcutaneously once a week.

Further dose increases: After at least 4 weeks on the current dose the dosage may be increased in 2.5 mg increments.

Recommended maintenance dose: 5 mg, 10 mg, or 15 mg injected subcutaneously once weekly.

Maximum dose: 15 mg subcutaneously once a week.

Usual adult Zepbound dose for obstructive sleep apnea

Initial dose: 2.5 mg under the skin (subcutaneously) once a week.

After 4 weeks: The dosage should be increased to 5 mg subcutaneously once a week.

Further dose increases: After at least 4 weeks on the current dose the dosage may be increased in 2.5 mg increments.

Recommended maintenance dose: 10 mg to 15 mg injected subcutaneously once weekly.

Maximum dose: 15 mg subcutaneously once a week.

Tell your doctor and pharmacist what prescription and nonprescription medications, vitamins, nutritional supplements, and herbal products you are taking or plan to take. Your doctor may need to change the doses of your medications or monitor you carefully for side effects.

Birth control pills may not work as well while receiving this medicine. Your doctor may suggest you use another form of birth control for 4 weeks after starting this medicine and for 4 weeks after each dose change. Talk to your healthcare provider about the best birth control methods that may be right for you while using this medicine.

Taking Zepbound with other medicines to treat diabetes, like insulin or sulfonylureas, may increase your risk of hypoglycemia. Talk to your doctor and pharmacist about low blood sugar and how to manage it.

Zepbound slows gastric emptying and so may change the absorption of other oral medicines that you take. Your doctor will monitor patients on oral medications that have a narrow therapeutic index (e.g., warfarin) or medicines that are dependent on threshold concentrations, while being treated with Zepbound.

This list is not complete. Many other drugs may interact with this medicine, including prescription and over-the-counter medicines, vitamins, and herbal products. Buy Zepbound Online

• Store in the refrigerator between 36⁰F to 46⁰F (2⁰C to 8⁰C).
• Do not freeze. Do not use if frozen.
• Store the single-dose pens in the original carton until use to protect them from light.
• If needed, each single-dose pen can be stored at room temperature up to 86⁰F (30⁰C) for up to 21 days.